Olfm4 and cancer

Author: olhj

August undefined, 2024

WebNational Center for Biotechnology Information Web02. maj 2024. · Moreover, the cancer stem cell-like property of OLFM4 mediated by leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), known as an intestinal stem …

Olfactomedin 4 down-regulates innate immunity against - PNAS

Web18. jul 2024. · Cancer molecular subtyping (describing cancer subtypes) is important not least because of its potential relevance to choice of treatment [1,2].In the case of Colon Cancer, classifications of colorectal cancers (CRC) can be subdivided into 3–6 subtypes, based on gene expression profiles [1,2,3,4].Alternatively, CRC has been shown to divide … Web19. nov 2015. · Loss of olfactomedin 4 (OLFM4) gene expression is associated with the progression of human prostate cancer, but its role and the molecular mechanisms involved in this process have not been ... tower bridge underground station

Network and functional analyses of differentially expressed genes …

Web01. jun 2016. · Development of colorectal cancer (CRC) is regulated by a series of genetic and microenvironmental alterations. Olfactomedin 4 (OLFM4) is a secreted glycoprotein … WebOlfactomedins (OLFMs) are a family of glycoproteins that play a relevant role in embryonic development and in some pathological processes. Although OLFM2 is involved in the regulation of the energy metabolism and OLFM4 is an important player in inflammation, innate immunity and cancer, the role of OLFMs in NAFLD-related intestinal dysbiosis … WebCytoreductive surgery and chemotherapy continue to be the mainstay of ovarian cancer treatment. However, as mortality from advanced ovarian cancer remains very high, novel therapies are required to be integrated into existing treatment regimens. Immunotherapy represents an alternative and rational therapeutic approach for ovarian cancer based on … powerapp last month

Olfactomedin 4 Is Not a Precise Marker for Human

Olfactomedin 4 expression and functions in innate immunity ...

Web27. maj 2024. · OLFM4 is highly expressed in polymorphonuclear bone marrow-derived inhibitory cells in colitis and colorectal cancer, its expression levels and cell populations are positively correlated with the ... Web10. jan 2007. · Overexpression of the olfactomedin 4 (OLFM4 GW112,/hGC−1) gene was recently reported to inhibit various apoptotic pathways and promote proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers.Therefore, we examined cancer-specific OLFM4 overexpression. OLFM4 … tower bridge type of bridgeWeb15. mar 2024. · Low expression of OLFM4 promoted lymph node and distant metastasis resulting in a poor prognosis of triple-negative breast cancer patients and low expression of OLFM4 in early gastric cancer was ... tower bridge travelodge london

"Web02. maj 2024. · Conclusion: OLFM4 is induced by the LGR5-Wnt signaling pathway and is strongly associated with aggressive tumor progression and poor prognosis in HCC by regulating STAT3-induced tumor cell proliferation and cancer stem cell–like property. Therefore, OLFM4 is a novel prognostic predictor and a potential therapeutic target for … " - Olfm4 and cancer

Olfm4 and cancer

OLFM4 Enhances STAT3 Activation and Promotes Tumor …

WebProtein function (UniProt)i. Useful information about the protein provided by UniProt. May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leu kemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 ... Web10. jan 2024. · Chemoresistance was observed by in vitro analysis of tumor cell lines with forced expression of OLFM4. In an assessment of tissue specimens from 80 patients with pancreatic cancer, Kaplan-Meier analysis showed that patients in the low OLFM4 expression group had a better survival rate than patients in the high OLFM4 expression …

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Web14. mar 2016. · Previous studies have shown that OLFM4 protein expression has been reduced or lost in a portion of human colon cancers, with loss being more prevalent in … WebOLFM4 is proved to as a functional target for miR-590. PMID: 28012926; Olfactomedin 4 is a novel tumor marker for triple-negative breast cancer for predicting and prognosis. PMID: 27939521; OLFM4 is downregulated by miR-486-5p, which contributes to …

WebP16、OLFM4在宫颈上皮内瘤变中的表达及其诊断意义.docx,P16、OLFM4在宫颈上皮内瘤变中的表达及其诊断意义摘要背景与目的：宫颈上皮内瘤变是常见妇科疾病，但因其表现多样化、易与非瘤变性病变混淆，因此需要寻找更准确、特异、敏感的标志物来辅助临床诊断。 Web10. apr 2024. · Gastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment of this complex disease. ... SFRP4, CDH17, FAP, CLDN1, and OLFM4 were of the highest LogFC values among the upregulated …

Web24. mar 2024. · OLFM4 is secreted and may be detected in serum and plasma therefore representing a good candidate CRC marker as previously suggested for gastric cancer [35, 36]. Sec24C is an essential coat protein II (COPII) component and COPII is involved in protein transports from the endoplasmic reticulum (ER).

WebAs a target gene of important signal pathways implicated in cancer and inflammation, OLFM4 may emerge as a potential therapeutic target for these diseases. Recent publications have also reported increased expression of OLFM4 in gastrointestinal cancer ( 10 – 13 ) and inflammatory disease including inflammatory bowel disease ( 14 ) and H ...

Web21. mar 2024. · OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Atrophy Of Prostate and Colonic Benign Neoplasm.Among its … tower bridge u bahn stationWeb10. jan 2007. · Overexpression of the olfactomedin 4 (OLFM4 GW112,/hGC−1) gene was recently reported to inhibit various apoptotic pathways and promote proliferation of … tower bridge \u0026 st paul\u0027s hotelWeb27. feb 2024. · A Data Scientist with pre-Sales Experience. Proven success in delivering transformational, never done before AI wins across the region, in both a startup and a large complex organization. A developer at heart but with an eye for practical AI and creating impact with technology. I’m a co-author of multiple Cancer publications and hold a MSc … power app languageWeb20. feb 2024. · 并且有文献指出，OLFM4在与富含亮氨酸重复序列G蛋白偶联受体5（leucinerich-repeat-containing G-protein-coupled receptor 5，Lgr5）关联的结肠癌干细胞中有表达[14-15]，而Lgr5与肿瘤的恶性程度直接相关，这也进一步证明了OLFM4与结肠癌肿瘤的分期相关，或许可将OLFM4 作为结肠癌 ... tower bridge typeWeb21. okt 2024. · OLFM4 expression is frequently lost or reduced in human small intestine adenocarcinoma and is correlated with tumor grade and stage. OLFM4 mRNA is … powerapp launch sharepoint linkWeb13. maj 2016. · OLFM4 expression is correlated with cancer differentiation, stage, metastasis, and prognosis in a variety of cancers, suggesting its potential clinical value … powerapp launch functionWeb28. dec 2024. · Development of colorectal cancer (CRC) is regulated by a series of genetic and microenvironmental alterations. Olfactomedin 4 (OLFM4) is a secreted glycoprotein … power app launch function