WebbSrc-homology-2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the PTPN11 gene, is a 593 amino acid classical non-receptor protein tyrosine phosphatase (PTP). SHP2 is involved in diverse signalling pathways such as RAS-MAPK, PI3K-AKT, JAK-STAT and PD-1/PD-L1. Webb3 apr. 2024 · Registered Office: IACS Ltd, 4 Matthew Parker St, Westminster, London SW1H 9NP. Registered in England No. 2717077. Web Design by MVG Media. Member …
BBP-398, IACS-13909 - Product Profiles - BCIQ
Webb3 nov. 2024 · IACS-13909 achieved dose-dependent plasma exposure at 24 hours after a single-dose treatment, and demonstrated dose-dependent suppression of DUSP6 … WebbIACS-13909, a specific and potent allosteric inhibitor of SHP2 that suppresses signaling through the MAPK pathway. IACS-13909 potently impeded proliferation of tumors harboring a broad telefono samsung j3 2016 prezzo
(PDF) Abstract C036: Discovery of IACS-13909, an allosteric SHP2 ...
WebbFor the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making. Unlike other intelligence solutions, BCIQ exclusively supports … WebbIACS-13909 was initially discovered as an SHP2 inhibitor by a team of scientists in MD Anderson's Institute for Applied Cancer Science (IACS) and Translational Research to Advance Therapeutics and WebbIACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website. Free shipping on inhibitor and protein orders over $500. More>> USD AUD GBP CAD EUR telefono sapu zapadores