Cisplatin renal function

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August undefined, 2024

WebFor cisplatin Monitoring of patient parameters Monitor full blood count. Monitor audiology. Monitor plasma electrolytes. Nephrotoxicity Monitoring of renal function is essential. … WebWhat Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, …

Cisplatin - Drug Information - Chemocare

WebJan 17, 2014 · Background Nephrotoxicity is the dose-limiting side effect of cisplatin justifying the assessment of renal function for dose adjustment. Objective To determine whether appropriate dose adjustment is made in patients with renal impairment using the Cockcroft–Gault (CG) or the abbreviated Modification of Diet in Renal Disease (aMDRD) … WebCisplatin, which is used as part of chemotherapeutic regimens for a wide array of different cancers, can cause acute kidney injury in 20–30% of cases. Cisplatin-induced nephrotoxicity is due to mitochondrial damage that is a consequence of increases in mitochondrial reactive oxygen species. raghupati raghav raja ram original ly

Advanced Bladder Cancer and Impaired Renal Function - Medscape

WebApr 14, 2024 · Nicotinamide deficiency has been linked to the damage of the renal tubular cells, especially proximal tubular cells. For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [ 29, 30 ]. WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. dra skid

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

WebIt covalently binds to DNA and disrupts DNA function. 6. After cisplatin enters the cells, the chloride ligands are replaced by water molecules. 7,8. ... is a major concern when prescribing cisplatin. Renal dysfunction due to cisplatin may manifest as renal insufficiency, hypokalemia and hypomagnesemia. ... WebApr 9, 2024 · The most common reason for cisplatin-ineligibility is renal function impairment. Up to 40% of patients with bladder cancer have renal impairment, defined … raghupati raghav raja ram songWebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … dr askenazi crystal lake

"WebMar 23, 2024 · Histologic evaluation and blood urea nitrogen (BUN) confirmed that renal structure and function were preserved 48 h after cisplatin injury. Similarly, weight loss was slowed down. " - Cisplatin renal function

Cisplatin renal function

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WebNephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate … WebMar 12, 2024 · Nephrotoxicity is a known side effect of several treatments, including cisplatin, carboplatin, ifosfamide, radiotherapy and nephrectomy, and can cause glomerular filtration rate (GFR) impairment, proteinuria, tubulopathy, and hypertension. Evidence about the long-term effects of these treatments on renal function remains inconclusive.

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WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … WebMar 13, 2024 · Background. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the …

WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … WebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the …

WebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National … WebJan 1, 2024 · Cisplatin can enter the renal tubular cells by either passive diffusion or active transport. Previous studies have indicated that movement of cisplatin through the renal …

WebFeb 16, 2016 · In our study using GFR as a measure for renal function, acute nephrotoxicity grade 2 was found in 11% of patients after the first course and in 16% after the second course of cisplatin. By comparison, when expressing nephrotoxicity in the same study population using serum creatinine levels, we observed a lower incidence of …

WebMar 2, 2024 · Cisplatin is a potent anticancer drug widely used for the treatment of several malignant tumors. One of the most relevant side effects of cisplatin is nephrotoxicity, that is very well-known since its introduction in 1978 and limits its use and efficacy [ 1, 2 ]. raghupati raghav raja ram soWebJan 11, 2024 · During and after cisplatin treatment. Renal function should be closely monitored before each dose of chemotherapy every 1–2 weeks. draskoWebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat Rev. 1995; 21: 33–64GFR (mL/min) Dose60 100%50–60 75%40–50 50%40 AvoidBennett 50 100%10–50 75% raghupati raghav raja ram origWebMain outcome measure: Cisplatin dose in mg/m(2) based on kidney function and according to the dosing recommendations. Results: Among 1,364 cycles of cisplatin, … raghu raghavan dxcWebFeb 23, 2024 · Cisplatin-based neoadjuvant chemotherapy is the standard of care for patients with muscle-invasive bladder cancer (MIBC). It yields a 30% to 40% pathologic … drasko brguljanWebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … drasko boljevicWebSep 1, 2024 · Cisplatin induces multiple intracellular injury pathways, including inflammation, oxidative stress, apoptotic pathways, and DNA damage mediating renal tubular cell injury. raghupati raghav raja ram song lyrics