WebThe ataxia-telangiectasia mutated (ATM) protein kinase is best known for its role in the DNA damage response, but recent findings suggest that it also functions as a redox sensor that controls the levels of reactive oxygen species in human cells. Here, we review the evidence supporting the conclusion that ATM can be directly activated by ... WebJul 27, 2024 · 1.2. DNA-PKcs and ATM. The molecular cloning of cDNA-encoding DNA-PKcs was achieved in 1995 and revealed its extremely large size, i.e., 4128 amino acids, which was even larger than expected before [].Another surprise was its similarity to Ataxia–telangiectasia mutated (ATM), the gene responsible for ataxia–telangiectasia …
ATM (タンパク質) - Wikipedia
WebMay 3, 2013 · The Ataxia Telangiectasia-Mutated (ATM) protein kinase is recruited to sites of double-strand DNA breaks by the Mre11/Rad50/Nbs1 (MRN) complex, which also … WebDec 10, 2007 · The ataxia–telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent ... sjt what\u0027s on
Tug of War between Survival and Death: Exploring ATM Function …
WebMar 13, 2013 · The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double … WebThe ataxia-telangiectasia mutated (ATM) protein and the nonhomologous end-joining (NHEJ) pathway play crucial roles in sensing and repairing DNA double-strand breaks in … WebMice mutated in the homologue of the ATM (ataxia telangiectasia mutated) gene (Atm) display similar pleiotropic defects (5, 27, 97). The ATM protein belongs to a growing family of phosphatidylinositol-3 kinase-related kinases and seems to play a role as an intrinsic part of the cell cycle machinery that surveys genomic integrity, cell cycle ... sutter health dr marks